Synthesis and Antibacterial Activity of 2-[o-imino-(4-thiazolidinone)-phenyl]-3-imino-(4-thiazolidinone)- 6-bromo Quinazolin-4(3H)-one from 2-(o-thiadiaminephenyl)-3-thiadiamine-6-bromo–quinazoline-4(3H)-one
Osarumwense Peter Osarodion
Issue:
Volume 8, Issue 1, June 2023
Pages:
1-5
Received:
4 April 2023
Accepted:
24 April 2023
Published:
10 May 2023
Abstract: Introduction: Broad range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities motivate us to synthesis some quinazolinone derivatives. These heterocycles are profitable intermediates in organic synthesis. Methods/Experimental: The compound 2-(o-thiadiaminephenyl)-3-thiadiamine-6-bromo–quinazoline-4(3H)-one (1), was produce when 2-(o-aminophenyl)-3-amino-6-bromo–Quinazolin-4(3H)-one (0.055M) was dissolved in minimum amount of dil. HCl in a round bottom flask. Ammonium thiocyanate (0.11M, 9.68gm) was then added and the mixture refluxed for 7 hrs. A mixture of 2-(o-thiadiaminephenyl)-3-thiadiamine-6-bromo–Quinazolin-4(3H)-one (0.037M, 16.095gm) and fused sodium acetate (0.074M, 6.068gm) was taken in absolute alcohol (300ml) and refluxed for 10 hours to give 6-bromo-2-[o-imino-(4-thiazolidinone)-phenyl]-3-imino-(4-thiazolidinone)-Quinazolin-4(3H)-one(2). These Compounds were evaluated for their antibacterial activity (against some gram positive and gram negative microorganism) and antifungal activity (against Candida albicans). Study Design: This study was experimentally design and the antibacterial activity was evaluated against some microorganism, Staphylococcus aureus, Bacillus species, Aspergillus Species, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, and candida albicans Result: The compounds exhibited significant antibacterial activity with a zone of inhibition in the range of 10 – 20mm in comparison to control. Conclusions: From our findings, the compounds synthesized have higher antibacterial activities against Staphylococcus aureus, Aspergillus Species, as compared to Ciprofloxicin (CPX) and Ketonaxol (PEF) standard antibacterial drugs.
Abstract: Introduction: Broad range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities motivate us to synthesis some quinazolinone derivatives. These heterocycles are profitable intermediates in organic synthesis. Methods/Experimental: The compound 2-(o-thiadiaminephenyl)-3-thiadiamine-6-bromo–quinaz...
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Research on Ceramic/Steel Connection Using the Composite Interlayer Method
Deshui Yu,
Yan Zhang,
Jianping Zhou,
Daqian Sun,
Hongmei Li
Issue:
Volume 8, Issue 1, June 2023
Pages:
6-9
Received:
17 July 2023
Accepted:
19 August 2023
Published:
31 August 2023
Abstract: Ceramics are widely used in harsh environments due to their excellent mechanical properties such as hardness, high melting point and resistance to wear. However, due to their brittle nature, ceramics are difficult to process in engineering applications, which greatly limits their widespread use. Metals, on the other hand, have superior plasticity and toughness, allowing for on-demand design and shaping in practical production. Therefore, by combining the wear and corrosion resistance of ceramics with the plasticity and ductility of metals, composite structural components are able to meet the requirements for the normal performance of material properties in harsh environments. The composite sandwich method is an ideal method for joining ceramics and metals, and shows superior mechanical properties when joining ceramics and metals. The use of composite interlayers not only realizes stable ceramic/metal joints, but also effectively mitigates the damage to ceramics caused by residual thermal stresses in the weld. This paper summarizes the research progress in recent years on the application of composite sandwich method to prepare ceramic/steel joints, and describes in detail the interfacial composition and mechanical properties of ceramic/metal joints. The effects of welding time and welding temperature on the interfacial composition and mechanical properties of the joints by the composite sandwich method are summarized.
Abstract: Ceramics are widely used in harsh environments due to their excellent mechanical properties such as hardness, high melting point and resistance to wear. However, due to their brittle nature, ceramics are difficult to process in engineering applications, which greatly limits their widespread use. Metals, on the other hand, have superior plasticity a...
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