Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina

Weiting Wang; Chunhua Hao; Zhuanyou Zhao

doi:doi:10.11648/j.sjcm.20170601.12

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Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina

Weiting Wang, Chunhua Hao, Zhuanyou Zhao

Published in Science Journal of Clinical Medicine (Volume 6, Issue 1)

Received: 12 February 2017 Accepted: 4 March 2017 Published: 21 March 2017

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Abstract

Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg^-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg^-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg^-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg^-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg^-1 administration, and the aggregation in TC 32 mg•kg^-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.

Published in	Science Journal of Clinical Medicine (Volume 6, Issue 1)
DOI	10.11648/j.sjcm.20170601.12
Page(s)	20-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Ticlopidine, Antiplatelet Aggregation, Unstable Angina Pectoris

References

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[2]	Dasbiswas A, Rao MS, Babu PR, Vijayvergiya R, Nayak R, Dani S, et al. A comparative evaluation of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention. J Assoc Physicians India. 2013, 61 (2): 114-116, 126.
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[5]	Osman HE. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys (macaca fasciularis). J Nutr 1998, 128: 2307-2312.
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[9]	Becker R C. Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation [J]. American Journal of Cardiology, 2014, 83 (9A): 3E-6E.
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[11]	Ikeda H, Koga Y, Kuwano K, Nakayama H, Ueno T, Yoshida N, et al. Cyclic flow variations in conscious dog model of coronary artery stenosis and endothelial injury correlate with acute ischemic heart disease syndromes in humans. J Am Coll Cardiol 1993; 21 (4): 1008-1017.
[12]	Zhang S, Sun C, Hu H, He Y, Yao Y, Cao Y, Zeng Z. Effects of Paclitaxel on the Ability of Aspirin and Clopidogrel to Inhibit Platelet Aggregation. Clin Appl Thromb Hemost. 2016, 22 (7): 673-678.
[13]	Christ G, Hafner T, Siller-Matula J M, et al. Platelet Inhibition by Abciximab Bolus-Only Administration and Oral ADP Receptor Antagonist Loading in Acute Coronary Syndrome Patients: The Blocking and Bridging Strategy. Thrombosis research, 2013, 132 (1): e36.
[14]	Weisman G A, Woods L T, Erb L, et al. P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.[J]. CNS & neurological disorders drug targets, 2012, 11 (6): 722-38.
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[16]	Di Minno G, Cerbone AM, Mattioli PL, Turco S, Iovine C, Mancini M. Functionally thrombasthenic state in normal platelets following the administration of ticlopidine.J Clin Invest 1985; 75 (2): 328-338.

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APA Style

Weiting Wang, Chunhua Hao, Zhuanyou Zhao. (2017). Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Science Journal of Clinical Medicine, 6(1), 20-23. https://doi.org/10.11648/j.sjcm.20170601.12

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ACS Style

Weiting Wang; Chunhua Hao; Zhuanyou Zhao. Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Sci. J. Clin. Med. 2017, 6(1), 20-23. doi: 10.11648/j.sjcm.20170601.12

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AMA Style

Weiting Wang, Chunhua Hao, Zhuanyou Zhao. Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Sci J Clin Med. 2017;6(1):20-23. doi: 10.11648/j.sjcm.20170601.12

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@article{10.11648/j.sjcm.20170601.12,
  author = {Weiting Wang and Chunhua Hao and Zhuanyou Zhao},
  title = {Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina},
  journal = {Science Journal of Clinical Medicine},
  volume = {6},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.sjcm.20170601.12},
  url = {https://doi.org/10.11648/j.sjcm.20170601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20170601.12},
  abstract = {Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg-1 administration, and the aggregation in TC 32 mg•kg-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.},
 year = {2017}
}

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TY  - JOUR
T1  - Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina
AU  - Weiting Wang
AU  - Chunhua Hao
AU  - Zhuanyou Zhao
Y1  - 2017/03/21
PY  - 2017
N1  - https://doi.org/10.11648/j.sjcm.20170601.12
DO  - 10.11648/j.sjcm.20170601.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 20
EP  - 23
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20170601.12
AB  - Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg-1 administration, and the aggregation in TC 32 mg•kg-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.
VL  - 6
IS  - 1
ER  -

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Author Information

Weiting Wang

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Chunhua Hao

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Zhuanyou Zhao

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

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Plain Text BibTeX RIS

APA Style

Weiting Wang, Chunhua Hao, Zhuanyou Zhao. (2017). Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Science Journal of Clinical Medicine, 6(1), 20-23. https://doi.org/10.11648/j.sjcm.20170601.12

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ACS Style

Weiting Wang; Chunhua Hao; Zhuanyou Zhao. Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Sci. J. Clin. Med. 2017, 6(1), 20-23. doi: 10.11648/j.sjcm.20170601.12

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AMA Style

Weiting Wang, Chunhua Hao, Zhuanyou Zhao. Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina. Sci J Clin Med. 2017;6(1):20-23. doi: 10.11648/j.sjcm.20170601.12

Copy | Download

@article{10.11648/j.sjcm.20170601.12,
  author = {Weiting Wang and Chunhua Hao and Zhuanyou Zhao},
  title = {Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina},
  journal = {Science Journal of Clinical Medicine},
  volume = {6},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.sjcm.20170601.12},
  url = {https://doi.org/10.11648/j.sjcm.20170601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20170601.12},
  abstract = {Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg-1 administration, and the aggregation in TC 32 mg•kg-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina
AU  - Weiting Wang
AU  - Chunhua Hao
AU  - Zhuanyou Zhao
Y1  - 2017/03/21
PY  - 2017
N1  - https://doi.org/10.11648/j.sjcm.20170601.12
DO  - 10.11648/j.sjcm.20170601.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 20
EP  - 23
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20170601.12
AB  - Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg-1 administration, and the aggregation in TC 32 mg•kg-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.
VL  - 6
IS  - 1
ER  -

Copy | Download