A cleaner production of various potentially anti-parasitic drugs based bis-(arylmethylidene)cycloalkanones have been developed using a heterogeneous catalysis technology in aqueous media without organic solvent. The higher activity and selectivity of our solid-state synthetic phosphate catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.
Published in |
American Journal of Environmental Protection (Volume 4, Issue 5-1)
This article belongs to the Special Issue Cleaner and Sustainable Production |
DOI | 10.11648/j.ajeps.s.2015040501.14 |
Page(s) | 33-36 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Green Synthesis, Heterogeneous Catalysis, Anti-Parasitic Drugs, Bis-(Arylmethylidene) Cycloalkanones, Synthetic Phosphate, Aqueous Media
[1] | WHO, World Health Organization. Available from: http://apps.who.int/tdr/svc/publications/tdrnews/tdr-news-issue-84 (accessed 02.22.10). |
[2] | J.A. Urbina, Parasitological cure of Chagas disease, Oswaldo Cruz. 94 (1999) 349-355. |
[3] | S.A. Grevelink, E.A. Lerner, Leishmaniasis, J. Am. Acad. Dermatol. 34 (1996) 257-272. |
[4] | S.L. Croft, G.H. Coombs, Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs, Trends Parasitol. 19 (2003) 502-508. |
[5] | R.B. Oliveira, A.B.M. Vaz, R.O. Alves, D.B. Liarte, C.L. Donnici, A.J. Romanha, C.L. Zani, Arylfurans as potential Trypanosoma cruzi trypanothione, Mem. Inst. Oswaldo Cruz 101 (2006) 169-173. |
[6] | F.P. Braga, V.P. Alves, R.S. Ferreira, R.B. Fradico, P.S. Lage, M.C. Duarte, T.G. Ribeiro, A.S. Júnior, A.J. Romanha, M.L. Tonini, M. Steindel, E.F. Coelho, R.B. Oliveira, Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones, European Journal of Medicinal Chemistry 71 (2014) 282-289. |
[7] | Y. Riadi, R. Mamouni, R. Azzalou, R. Boulahjar, Y. Abrouki, M. El Haddad, S. Routier, G. Guillaumet, S. Lazar, Animal bone meal as an efficient catalyst for crossed-aldol condensation, Tetrahedron Letters 51 (2010) 6715-6717 |
[8] | P. Salehi, M. Dabiri, M.A. Zolfigol, M.B. Fard, Silica sulfuric acid as an efficient and reusable reagent for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions, J. Braz. Chem. Soc. 15 (2004) 773-776. |
[9] | M.S. Abaee, M.M. Mojtahedi, S. Forghani, N.M. Ghandchi, M. Forouzani, R. Sharifi, B. Chaharnazm, A Green, inexpensive and efficient organocatalyzed procedure for aqueous aldol condensations, J. Braz. Chem. Soc. 20 (2009) 1895-1900. |
[10] | M.S. Abaee, M.M. Mojtahedi, R. Sharifi, M.M. Zahedi, H. Abbasi, K. Tabar- Heidar, Facile synthesis of bis(arylmethylidene)cycloalkanones mediated by lithium perchlorate under solvent-free conditions, Iran. J. Chem. Soc. 3 (2006) 293-296. |
[11] | Y. Abrouki, M. Zahouily, A. Rayadh, B. Bahlaouan, S. Sebti, A natural phosphate and doped-catalyzed Michael addition of mercaptans to α,β-unsaturated carbonyl compounds, Tet. Lett., 43, (2002), pp. 8951-8953. |
[12] | M. Zahouily, Y. Abrouki, A. Rayadh, S. Sebti, H. Dhimane, M. David, Fluorapatite: efficient catalyst for the Michael addition, Tet. Lett., 44 (2003), 2463-2465. |
[13] | A Solhy, A Smahi, H El Badaoui, B Elaabar, A. Amoukal, A. Tikad, S. Sebti, D.J. Macquarrie, Efficient hydration of nitriles to amides catalysed by sodium nitrate modified fluorapatite, Tet. Lett., 44 (2003), 4031-4033. |
[14] | Y. Abrouki, A. Anouzla, H. Loukili, R. Lotfi, A. Rayadh, M.A. Bahlaoui, S. Sebti, D. Zakarya, M. Zahouily, Central composite experimental design applied to the catalytic carbon-sulfur bond formation by fluorapatite catalyst, American Journal of Applied Chemistry, 1 (2013), 22-27. |
APA Style
Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaa Lotfi, Ahmed Rayadh, et al. (2015). An Eco-Friendly Paradigm for the Production of Potentially Anti-Parasitic Drugs. American Journal of Environmental Protection, 4(5-1), 33-36. https://doi.org/10.11648/j.ajeps.s.2015040501.14
ACS Style
Younes Abrouki; Abdelkader Anouzla; Hayat Loukili; Rabiaa Lotfi; Ahmed Rayadh, et al. An Eco-Friendly Paradigm for the Production of Potentially Anti-Parasitic Drugs. Am. J. Environ. Prot. 2015, 4(5-1), 33-36. doi: 10.11648/j.ajeps.s.2015040501.14
AMA Style
Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaa Lotfi, Ahmed Rayadh, et al. An Eco-Friendly Paradigm for the Production of Potentially Anti-Parasitic Drugs. Am J Environ Prot. 2015;4(5-1):33-36. doi: 10.11648/j.ajeps.s.2015040501.14
@article{10.11648/j.ajeps.s.2015040501.14, author = {Younes Abrouki and Abdelkader Anouzla and Hayat Loukili and Rabiaa Lotfi and Ahmed Rayadh and My Abdellah Bahlaoui and Driss Zakarya and Mohamed Zahouily and Rachid Mamouni and Saïd Sebti and Adil Mandil}, title = {An Eco-Friendly Paradigm for the Production of Potentially Anti-Parasitic Drugs}, journal = {American Journal of Environmental Protection}, volume = {4}, number = {5-1}, pages = {33-36}, doi = {10.11648/j.ajeps.s.2015040501.14}, url = {https://doi.org/10.11648/j.ajeps.s.2015040501.14}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajeps.s.2015040501.14}, abstract = {A cleaner production of various potentially anti-parasitic drugs based bis-(arylmethylidene)cycloalkanones have been developed using a heterogeneous catalysis technology in aqueous media without organic solvent. The higher activity and selectivity of our solid-state synthetic phosphate catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.}, year = {2015} }
TY - JOUR T1 - An Eco-Friendly Paradigm for the Production of Potentially Anti-Parasitic Drugs AU - Younes Abrouki AU - Abdelkader Anouzla AU - Hayat Loukili AU - Rabiaa Lotfi AU - Ahmed Rayadh AU - My Abdellah Bahlaoui AU - Driss Zakarya AU - Mohamed Zahouily AU - Rachid Mamouni AU - Saïd Sebti AU - Adil Mandil Y1 - 2015/05/22 PY - 2015 N1 - https://doi.org/10.11648/j.ajeps.s.2015040501.14 DO - 10.11648/j.ajeps.s.2015040501.14 T2 - American Journal of Environmental Protection JF - American Journal of Environmental Protection JO - American Journal of Environmental Protection SP - 33 EP - 36 PB - Science Publishing Group SN - 2328-5699 UR - https://doi.org/10.11648/j.ajeps.s.2015040501.14 AB - A cleaner production of various potentially anti-parasitic drugs based bis-(arylmethylidene)cycloalkanones have been developed using a heterogeneous catalysis technology in aqueous media without organic solvent. The higher activity and selectivity of our solid-state synthetic phosphate catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents. VL - 4 IS - 5-1 ER -